The effect of lithium tetraborate as a novel cardioprotective agent after renal ischemia-reperfusion injury

Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, employed vivo rat model with ischemia reperfusion to evaluate cardiac clarify mechanisms of tetraborate. The evaluation through artery occlusion indicated could (1) reduce oxidative stress-induced endothelial dysfunction; (2) attenuate inflammatory response cells; (3) alleviate apoptosis necrosis myocytes. summary, demonstrates significant therapeutic properties contribute amelioration damage, it be promising candidate future applications dysfunction.